Figure 4(c).

Quality assessment of economic evaluation studies.

Questions:

Q1. Is there a well-defined question?

Q2. Is there a comprehensive description of alternatives?

Q3. Are all important and relevant costs and outcomes for each alternative identified?

Q4. Has clinical effectiveness been established?

Q5. Are costs and outcomes measured accurately?

Q6. Are costs and outcomes valued credibly?

Q7. Are costs and outcomes adjusted for differential timing?

Q8. Is there an incremental analysis of costs and consequences?

Q9. Were sensitivity analyses conducted to investigate uncertainty in estimates of cost or consequences?

Q10. Do study results include all issues of concern to users?

Q11. Are the results generalizable to the setting of interest in the review?