Table 2.
Study | Target | Stimulation parameters | Number of patients | Age | Gender | Initial BMI | BMI after DBS | Follow up (months) | Comorbidities |
---|---|---|---|---|---|---|---|---|---|
Wang and colleagues124 | NAc | 135–185 Hz, 120–210 µs pw, 2.5–3.8 V | 2 | 18–28 | Female | 12.9–13.3 | 18–21 | 12 | (1) OCD, depression, anxiety; (2) depression, anxiety |
Wu and colleagues125 | NAc | 180 Hz, 90 µs pw | 4 | 16–17 | Female | 10–13.3 | 17–22 | 9–50 | (1) OCD; (2) OCD; (3) OCD; (4) Anxiety disorder |
Israel and colleagues126 | SCC | Right-sided: 130 Hz, 91 µs pw, 5 mA | 1 | 52 | Female | 14.4 | 19 | 30 | Depression |
Lipsman and colleagues,127 Lipsman et al.128 | SCC | 130 Hz, 90 µs pw, 5–6 V | 16 | 34 | Female | 13.8 ± 1.5 | 17.3 ± 3.4 | 12 | |
McLaughlin and colleagues 119 | VC/VS | 120 Hz, 120 µs pw, 7.5 V | 1 | 52 | Female | 18.5 | OCD, depression | ||
Blomstedt and colleagues129 | BNST | 130 Hz, 120 µs pw, 4.3 V | 1 | 60 | Female | 15.2 | 14.3 | 12 |
BNST: bed nucleus of stria terminalis; NAc: nucleus accumbens; OCD: obsessive-compulsive disorder; pw: pulse width; SCC, subgenual cingulate cortex; VC/VS: ventral capsule/ventral striatum.