TUMOR	ABERRATION	GENES INVOLVED
Malignant Round Cell Tumors
Ewing's sarcoma/peripheral neuroectodermal tumor	t(11;22)(q24;q12) t(21;22)(q22;q12) other rare variants	EWS-FLI1 EWS-ERG various
Desmoplastic small round cell tumor	t(11;22)(p13;q12)	EWS-WT1
Embryonal rhabdomyosarcoma	Complex alterations	Unknown
Alveolar rhabdomyosarcoma	t(2;13)(q35;q14) t(1;13)(p36;q14)	PAX3-FKHR PAX7-FKHR
Lipomatous Tumors
Myxoid/round cell liposarcoma	t(12;16)(q13;p11)	TLS-CHOP
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS)	Supernumerary ring chromosomes; giant marker chromosomes	Amplification of region 12q14-15, including MDM2, CDK4, HMGA2, SAS, GL1
Dedifferentiated liposarcoma	Same as for ALT/WDLPS	Same as for ALT/WDLPS
Pleomorphic liposarcoma	Complex alterations	Unknown
Other Sarcomas
Alveolar soft part sarcoma	der(17)(X;17)(p11;q25)	ASPL-TFE3
Angiomatoid fibrous histiocytoma	t(2;22)(q33;q12) t(12;16)(q13;p11)	EWS-CREB1 TLS-ATF1
Clear cell sarcoma	t(12;22)(q13;q12) t(2;22)(q33;q12)	EWS-ATF1 EWS-CREB1
Congenital/infantile – fibrosarcoma	t(12;15)(p13;q25)	ETV6-NTRK3
Dermatofibrosarcoma protuberans	t(17;22)(q22;q13) and derivative ring chromosomes	COL1A1-PDGFB
Desmoid fibromatosis	Trisomy 8 or 20; loss of 5q	CTNNB1 or APC mutations
Epithelioid sarcoma (proximal type)	Bi-allelic inactivation of 22q11.2	INI1
Extrarenal rhabdoid tumor	Bi-allelic inactivation of 22q11.2	INI1
Extraskeletal myxoid chondrosarcoma	Rearrangements of 9q22	CHN
Sporadic GIST Familial GIST (Carney-Stratakis syndrome)	Activating kinase mutations KREBS cycle mutation	KIT or PDGFRA SDH subunit mutations
Inflammatory myofibroblastic tumor	Rearrangements of 2p23	ALK
Leiomyosarcoma	Complex alterations	Unknown
Low-grade fibromyxoid sarcoma	t(7;16)(q34;p11)	TLS-BBF2H7
Malignant peripheral nerve sheath tumor	Complex alterations	Unknown
Synovial sarcoma	t(X;18)(p11;q11) t(X;18)(p11;q11)	SYT-SSX1 SYT-SSX2
Tenosynovial giant cell tumor/pigmented villonodular synovitis (TGCT/PVNS)	t(1;2)(p13;q35)	CSF1