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. Author manuscript; available in PMC: 2018 Jan 29.
Published in final edited form as: Cell Rep. 2018 Jan 9;22(2):456–470. doi: 10.1016/j.celrep.2017.12.044

Figure 7. Defective Sensorimotor Gating in Plxna2−/− and Plxna2R/R Mice.

Figure 7

(A) Testing of the startle amplitude of male Plxna2+/+ (n = 8), Plxna2+/− (n = 9), and Plxna2−/− (n = 12) mice to a 120-dB sound.

(B) Percentile of PPI of the same cohort of mice with a prepulse delivered at 12 kHz or as broadband noise (BBN) at 40, 50, and 65 dB prior to the 120-dB startle sound.

(C) Testing of the startle amplitude of female Plxna2+/+ (n = 12), Plxna2+/− (n = 10), and Plxna2−/− (n = 9) mice to a 120-dB sound.

(D) Percentile of PPI of the same cohort of mice with a prepulse delivered at 12 kHz or as BBN at 40, 50, and 65 dB prior to the 120-dB startle sound.

(E) Testing of the startle amplitude of Plxna2+/+ (n = 13), Plxna2R/+ (n = 12), and Plxna2R/R (n = 13) mice to a 120-dB sound.

(F) Percentile of PPI of the same cohort of mice with a prepulse delivered at 12 kHz or as BBN at 40, 50, and 65 dB prior to the 120-dB startle sound.

Data are presented as mean ± SD in (A), (C), and (E); **p < 0.01, ***p < 0.001, and ****p < 0.0001, by one-way ANOVA, with Tukey post hoc t test. Error bars indicate SEM in (B), (D), and (F); **p < 0.01, ***p < 0.001, and ****p < 0.0001, by two-way ANOVA, with Fisher’s least significant difference (LSD). ns, not significant.