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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Neurochem. 2017 Nov 22;143(6):736–749. doi: 10.1111/jnc.14211

Figure 9.

Figure 9

AbSL binding site is proximal to, but distinct from, the N-terminal Aβ antibody binding site. Panel A. Utilizing the indirect sandwich ELISA format detailed in Figure 8A, increasing amounts of Aβ42 were added to immunoplates previously coated with primary antibodies Ab2.1.3 (Panel A) or Ab9 (Panel B). Detection was accomplished with AbSL antiserum followed by an anti-rabbit IgG-HRP secondary detection antibody. Sample data points are the mean of n = 3 replicates ± SEM and demonstrate a similar affinity of AbSL for protofibrils even in the presence of Ab9.