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Representative calcium transient of FLS in response to fluid-induced shear stress. [Ca2+]i is steady at equilibrium, rises sharply with flow onset to maximum value (peak magnitude) after slight delay (peak latency), then returns to equilibrium levels. Area under curve (AUC, dashed region) indicates total calcium flux. Fluorescence intensity of calcium indicator dye is normalized to average value prior to flow and set at 1 to represent relative changes in [Ca2+]i.
