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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Biomed Inform. 2017 Nov 29;77:50–61. doi: 10.1016/j.jbi.2017.11.016

Figure 3.

Figure 3

Demonstration of the Unique Inherited Configuration support (UICsup) metric. (A) Various examples of SNP inheritance patterns from mothers (“M”) and fathers (“F”) to probands (“P”) and their unaffected siblings (“S”). Bars across chromatids represent a SNP minor allele. Circles highlight when SNPs are homozygous for all the minor alleles of the SNP-set in question, equivalently indicating when a person would be assigned the item for the SNP-set. Note that all these probands have the depicted items. The right column indicates whether the proband has a unique configuration of inherited variants, and therefore is included in the UICsup. Families 1 and 2 show single-SNP inheritance patterns; families 3 and 4 show how the metric is applied for 2-SNP inheritance patterns. Family 1 and 3 probands do not have a unique configuration of the inherited variants because a non-proband family member has the item. Family 2 and 4 probands do have unique configurations of the inherited variants because they are the only family members with all the items in the SNP-set. (B) Example calculation of the support and UICsup of an SNP-set.