. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: J Biomed Inform. 2017 Nov 29;77:50–61. doi: 10.1016/j.jbi.2017.11.016

Table 3.

The three most significant genes and gene pairs associated with each subgroup 3.7 Availability of discovered genes

Subgroup	Most Significant Genes (adj. p-value)	Subgroup	Most Significant Genes (adj. p-value)

	Most Significant Gene Pairs (adj. p-value)		Most Significant Gene Pairs (adj. p-value)

dysmorphic	DYNC2H1 (0.0046) ^*	nondysmorphic	MXRA5Y (2.0e-06) ^nc
	AC008271.1 (0.0116) ^nc		IL1RAPL2 (0.0001) ^a,^p
	IGF2BP1 (0.0135) ^*		MAMLD1 (0.0003) ^*

	DYNC2H1 \| HMGB1P32 (0.0135) ^* \| ^nc		HS6ST2 \| OFD1P6Y (0.0080) ^* \| ^nc
	NRAP \| HS6ST2 (0.0148) ^* \| ^*		USP26 \| OFD1P6Y (0.0111) ^* \| ^nc
	CSNK1G3 \| HMGB1P32 (0.0148) ^*\| ^nc		-

high-severity awareness	NR6A1 (0.0027) ^*	low-severity awareness	-
	ZNF559 (0.0027) ^a		-
	ZNF559-ZNF177 (0.0027) ^*		-

	-		-
	-		-
	-		-

high-severity cognition	DRP2 (1.0e-48) ^p	low-severity cognition	UPF3B (0.0368) ^a,^p
	PTCHD1-AS (1.0e-48) ^nc		SHROOM4 (0.0368) ^p
	PCDH11X (3.26e-16) ^p		-

	GRIA3 \| TTTY5 (0.0079) ^p \| ^nc		-
	PTCHD1-AS \| TTTY5 (0.0119) ^nc \| ^nc		-
	DRP2 \| TTTY5 (0.0197) ^p \| ^nc		-

high-severity communication	HUWE1 (1.0e-48) ^a,^p	low-severity communication	DMD (0.0349) ^a,^p
	PCDH11Y (7.0e-47) ^p		CA5B (0.0484) ^*
	RP11-158M9.1 (7.6e-18) ^nc		-

	DMD \| TTTY5 (0.0042) ^a,^p \| ^nc		-
	RP13-126P21.2 \| TTTY5 (0.0044) ^nc \| ^nc		-
	SLC25A14 \| TTTY5 (0.0071) ^a,^p\| ^nc		-

high-severity mannerism	NLGN4X (2.5e-11) ^a,^p	low-severity mannerism	-
	GRP173 (1.2e-10) ^*		-
	RP11-268G12.1 (1.2e-10) ^nc		-

	PTCHD1-AS \| TTTY5 (0.0012) ^nc \| ^nc		-
	TMEM164 \| TTTY5 (0.0039) ^* \| ^nc		-
	TMEM164 \| TTTY11 (0.0244) ^* \| ^nc		-

high-severity motivation	LYPD5 (1.3e-11) ^*	low-severity motivation	TAF7L (4.8e-07) ^*
	TTTY5 (3.1e-07) ^nc		PDK3 (0.0003) ^*
	TTTY11 (5.7e-06) ^nc		DRP2 (0.0003) ^p

	LYPD5 \| IL1RAPL2 (0.0058) ^* \| ^a,^p		-
	LYPD5 \| PCDH11X (0.0148) ^* \| ^p		-
	-		-

gene novel to this study (not present in AutDB or PubMed abstract search)

gene present in AutDB

gene found in PubMed abstract search

^nc

non-coding gene – various RNAs that are expressed but not translated