Table 4. Hub genes and connected transcriptional regulators in blue module.
Gene Symbol | Entrez Gene Name | logFC | P_value | Counts | TFs |
---|---|---|---|---|---|
RASGRP2 | RAS guanyl releasing protein 2 | 2.088827 | 1.03E-06 | 39 | AP-2alphaA, AP-2gamma, ARNT, CREB1, DAND5, E2F, E2F1, EGR1, EGR2, EGR3, IRF1, IRF2, MAX, MEF2A, MIA3, MYC, MYCN, MZF1, NF-kappaB1, NF1, NFKB1, NKX2-5, PATZ1, PAX5, POU2F1, PPAR-gamma1, PPAR-gamma2, PPARA, PSG1, RORalpha1, RORalpha2, SP1, SPZ1, USF1, YY1, ZEB1, ZNF423, ZSCAN1, deltaCREB, |
IKZF1 | IKAROS family zinc finger 1 | 1.627103 | 0.00026 | 29 | AHR, AP-2alphaA, AP-2gamma, ARNT, CREB1, CUX1, DAND5, E2F, E2F1, EGR1, EP300, HMX3, MIA3, MYC, MZF1, Max1, PAX5, PELP1, PSG1, SP1, TFAP4, TP53, USF1, XBP1, XBP1P1, YY1, ZNF423, ZSCAN1, deltaCREB, |
CXCR5 | C-X-C motif chemokine receptor 5 | 2.765785 | 4.34E-08 | 23 | AML1a, ATF-2, C/EBPalpha, CEBPA, CREB1, DDIT3, FOS, FOSB, GATA1, JUN, JUNB, JUND, LMO2, NF-AT1, NF-AT2, NF-AT3, NF-AT4, PLAU, PPAR-gamma1, PPAR-gamma2, STAT5A, TCF3, deltaCREB, |
LTB | lymphotoxin beta | 1.467307 | 0.00969 | 14 | C/EBPalpha, CEBPA, DAND5, Elk-1, FOXD1, FOXF2, MZF1, PATZ1, PAX5, POU2F1, PSG1, SP1, TFAP4, ZSCAN1, |
BLK | BLK proto-oncogene, Src family tyrosine kinase | 2.791161 | 5.74E-08 | 11 | BPTF, ER-alpha, ESR1, LMO2, MEF2A, PPAR-gamma1, PPAR-gamma2, STAT5A, TAL1, TCF3, Tal-1beta, |
LINGO3 | leucine rich repeat and Ig domain containing 3 | 1.615729 | 0.001714 | 11 | EGR1, GATA1, HMX3, HSF1 (long), MZF1, PELP1, Pax-2, STAT1, STAT1alpha, STAT1beta, ZSCAN1, |
CCR6 | C-C motif chemokine receptor 6 | 1.675378 | 0.000302 | 10 | AML1a, ATF-2, HNF1A, Oct-B1, POU2F1, POU2F2, POU2F2B, POU2F2C, oct-B2, oct-B3, |
P2RY10 | purinergic receptor P2Y10 | 1.978882 | 1.54E-05 | 10 | AML1a, C/EBPalpha, CEBPA, NF-kappaB1, NF-kappaB2, NFKB1, POU2F1, Pbx1a, REL, RELA, |
RHOH | ras homolog family member H | 1.973277 | 5.15E-06 | 10 | IRF1, NF-AT1, NF-AT2, NF-AT3, NF-AT4, Pax-2, TAL1, TCF3, TCF4, Tal-1beta, |
log2FC: log2 fold change; TFs: transcriptional regulators.