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. 2018 Jan 29;13(1):e0190447. doi: 10.1371/journal.pone.0190447

Table 4. Hub genes and connected transcriptional regulators in blue module.

Gene Symbol Entrez Gene Name logFC P_value Counts TFs
RASGRP2 RAS guanyl releasing protein 2 2.088827 1.03E-06 39 AP-2alphaA, AP-2gamma, ARNT, CREB1, DAND5, E2F, E2F1, EGR1, EGR2, EGR3, IRF1, IRF2, MAX, MEF2A, MIA3, MYC, MYCN, MZF1, NF-kappaB1, NF1, NFKB1, NKX2-5, PATZ1, PAX5, POU2F1, PPAR-gamma1, PPAR-gamma2, PPARA, PSG1, RORalpha1, RORalpha2, SP1, SPZ1, USF1, YY1, ZEB1, ZNF423, ZSCAN1, deltaCREB,
IKZF1 IKAROS family zinc finger 1 1.627103 0.00026 29 AHR, AP-2alphaA, AP-2gamma, ARNT, CREB1, CUX1, DAND5, E2F, E2F1, EGR1, EP300, HMX3, MIA3, MYC, MZF1, Max1, PAX5, PELP1, PSG1, SP1, TFAP4, TP53, USF1, XBP1, XBP1P1, YY1, ZNF423, ZSCAN1, deltaCREB,
CXCR5 C-X-C motif chemokine receptor 5 2.765785 4.34E-08 23 AML1a, ATF-2, C/EBPalpha, CEBPA, CREB1, DDIT3, FOS, FOSB, GATA1, JUN, JUNB, JUND, LMO2, NF-AT1, NF-AT2, NF-AT3, NF-AT4, PLAU, PPAR-gamma1, PPAR-gamma2, STAT5A, TCF3, deltaCREB,
LTB lymphotoxin beta 1.467307 0.00969 14 C/EBPalpha, CEBPA, DAND5, Elk-1, FOXD1, FOXF2, MZF1, PATZ1, PAX5, POU2F1, PSG1, SP1, TFAP4, ZSCAN1,
BLK BLK proto-oncogene, Src family tyrosine kinase 2.791161 5.74E-08 11 BPTF, ER-alpha, ESR1, LMO2, MEF2A, PPAR-gamma1, PPAR-gamma2, STAT5A, TAL1, TCF3, Tal-1beta,
LINGO3 leucine rich repeat and Ig domain containing 3 1.615729 0.001714 11 EGR1, GATA1, HMX3, HSF1 (long), MZF1, PELP1, Pax-2, STAT1, STAT1alpha, STAT1beta, ZSCAN1,
CCR6 C-C motif chemokine receptor 6 1.675378 0.000302 10 AML1a, ATF-2, HNF1A, Oct-B1, POU2F1, POU2F2, POU2F2B, POU2F2C, oct-B2, oct-B3,
P2RY10 purinergic receptor P2Y10 1.978882 1.54E-05 10 AML1a, C/EBPalpha, CEBPA, NF-kappaB1, NF-kappaB2, NFKB1, POU2F1, Pbx1a, REL, RELA,
RHOH ras homolog family member H 1.973277 5.15E-06 10 IRF1, NF-AT1, NF-AT2, NF-AT3, NF-AT4, Pax-2, TAL1, TCF3, TCF4, Tal-1beta,

log2FC: log2 fold change; TFs: transcriptional regulators.