Table 1. Clinical and epidemiological description of 180 HNSCC cases from the three studies.

	STUDY
	ARCAGE (Czech Republic, Italy, Greece)		GENCAPO (Brazil)		LA (Argentina)		Total
Sex*	n	%	n	%	n	%	n	%
Female	26	28.57	2	3.85	5	13.51	33	18.33
Male	65	71.43	50	96.15	32	86.49	147	81.67
Age group
18 to 50	18	19.78	9	17.31	7	18.92	34	18.89
51 to 60	25	27.47	28	53.85	14	37.84	67	37.22
61 to 70	28	30.77	10	19.23	9	24.32	47	26.11
>70	20	21.98	5	9.62	7	18.92	32	17.78
Subsite*
Oral cavity	32	35.16	14	26.92	13	35.14	59	32.78
Oropharynx	30	32.97	10	19.23	5	13.51	45	25
Hypopharynx	2	2.2	11	21.15	0	0	13	7.22
Larynx	17	18.68	3	5.77	12	32.43	32	17.78
Overlapping	10	10.99	12	23.08	7	18.92	29	16.11
No information	0	0	2	3.85	0	0	2	1.11
Stage*
T1	8	8.79	1	1.92	0	0	9	5
T2	25	27.47	9	17.31	0	0	34	18.89
T3	16	17.58	17	32.69	3	8.11	36	20
T4	40	43.96	19	36.54	34	91.89	93	51.67
No information	2	2.2	6	11.54	0	0	8	4.44
Nodal Status*
N0	50	54.95	14	26.92	3	8.11	67	37.22
N+	38	41.76	27	51.92	8	21.62	73	40.56
No information	3	3.30	11	21.11	26	70.27	40	22.22
Smoking*
Non-smoker	18	19.78	1	1.92	3	8.11	22	12.22
Former smoker	13	14.29	14	26.92	6	16.22	33	18.33
Current smoker	60	65.93	32	61.54	28	75.68	120	66.67
No information	0	0	5	9.62	0	0	5	2.78
Alcohol*
Non-drinker	7	7.69	2	3.85	6	16.22	15	8.33
Former drinker	11	12.09	18	34.62	4	10.81	33	18.33
Current drinker	73	80.22	26	50	27	72.97	126	70
No information	0	0	6	11.54	0	0	6	3.33
HPV Status (HPV16E6 serology)
Negative	82	90.11	47	90.38	34	91.89	163	91.57
Positive	9	9.89	3	5.77	3	8.11	15	8.43
No information	0	0	2	3.85	0	0	2	1.11

*p value<0.05