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. 2017 Nov 14;16(24):2374–2385. doi: 10.1080/15384101.2017.1380136

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Figure 2. — Clinical roles of FBXW7 in patients with NSCLC. (A) The copy number variation of FBXW7 in NSCLC patients, and the genomic alternation is nearly 8% among 119 patients (http://www.cbioportal.org/). (B) The alternation of both mutation and deletion of FBXW7 was referred to shorter disease free survival (http://www.cbioportal.org/). (C-D) Higher level of FBXW7 was correlated with improved overall survival time in about 2000 cases, and means longer survival time before first progression occurred in about 1500 cases (http://kmplot.com/analysis/index.php?p = service&cancer = lung). (E-F) Kaplan-Meier plots results of clinic-pathologic parameter of NSCLC showed no significant differences in cases with or without Let-7c alternations.