Table 3.

Alterations of TJ proteins in intestines from IBD patients, IBD animal models, and CRC patients.

IBD patient intestines
	Occludin	ZO-1	Claudin-1	Claudin-2	Claudin-3	Claudin-4	Claudin-5	Claudin-7	Claudin-8	Claudin-18	Claudin-23	References
UC	—	↓		↑		↓						[4]
				↑	↓	↓						[90]
	—		↑	↑		↑						[91]
	—	—	↑	—	↑	↑						[92]
			↑	↑		↓		↓				[93]
										↑		[94]
CD	—	↓		↑		↓						[4]
	↓		—	↑		—	↓	—	↓			[86]
				↑	↓	↓						[90]
IBD animal intestines
DSS-induced colitis		↓										[100]
	↓				↓							[101]
TNBS-induced colitis										↑		[94]
	↓			—								[104]
		↑										[105]
SAMP1/Yit mice	↓			↑								[109]
CRC patient intestines
	↑	↑	↑	↑	↑	↑	↑					[112]
			↑									[116, 120, 122]
										↑		[114]
								↑				[113]
			↑			↑						[109]
						↓						[118]
			↑		↑	↑		—				[119]
								↓				[121, 124]
											↑	[123]

Note. “↑” increase; “↓” decrease; “ - ” no difference in the intestinal epithelium. Empty space: did not detect