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A Smear- or culture-positive patients at risk for MDR-TB without prior treatment history |
Subjects may be referred for DST if they 1) are diagnosed with smear-positive pulmonary TB, 2) have no prior history of anti-tuberculosis treatment, and 3) have at least one of the following risk factors:
Household contact of patient with documented MDR-TB or suspected MDR-TB (i.e., in treatment with second-line drugs, failed anti-tuberculosis treatment or died of TB in past 2 years) HIV-positive by ELISA and Western Blot confirmation Diabetes mellitus Health care worker by profession, regardless of health care field, in the last 2 years Student of health sciences in the last 2 years Incarcerated or employee of the penitentiary system in past 2 years Chronic treatment with corticosteroids Other condition of immunosuppression Adverse reaction to TB medications that has required a change in regimen Hospitalization for any indication in the last 2 years lasting more than 15 days Suspected treatment failure of Category I or II regimen (i.e., smear- or culture-positive between 2 and 4 months of treatment).
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B Patients who have received at least one previous course of treatment |
Subjects may be referred for DST if they have any of the prior TB treatment histories:
Abandoned any previous regimen and now present for retreatment Relapsed after completion of any previous regimen within less than 6 months Failed treatment with any previous regimen Received multiple courses of anti-tuberculosis treatment Have a history of private or self-administered treatment.
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C Confirmed or suspected smear-negative TB among high-risk groups (tested by BACTEC™) |
Subjects may be referred for DST if they 1) are suspected or confirmed to have active pulmonary TB, 2) are smear-negative, and 3) have at least one of the following risk factors:
Pediatric household contact of patient with documented MDR-TB Pediatric household contact of patient who has died of TB within the past 2 years HIV-positive by ELISA and Western Blot confirmation.
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