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. Author manuscript; available in PMC: 2018 Jan 29.
Published in final edited form as: Methods Enzymol. 2016 Jul 22;577:359–388. doi: 10.1016/bs.mie.2016.05.057

Fig. 4.

Fig. 4

Superposition comparison of snapshots of the Michaelis complex (blue) and transition state (brown) structures for the wild-type enzyme dihydrofolate reductase (left) and the M42W/G121V double mutant (right).