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. 2017 Oct 5;13(11):1998–1999. doi: 10.1080/15548627.2017.1327511

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© 2017 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Schematic representation of the sequential events occurring after mitochondrial depolarization. (1) Depolarization triggers recruitments of PINK1, PRKN, and LRRK2 to RHOT1. (2) These proteins target RHOT1 for removal from the OMM of damaged mitochondria causing mitochondrial arrest. (3) RHOT1 is subsequently degraded by proteasomes. (4) Mitochondria are ultimately degraded in lysosomes via mitophagy. MT, microtubules.