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Lpg1137 cleaves STX17, and prevents autophagy and apoptosis. STX17 participates in mitochondrial division in fed cells, and autophagosome formation and fusion with lysosomes in starved cells. Lpg1137, which is delivered into the host cell cytosol, cleaves STX17 and thereby abrogates autophagy by preventing PtdIns3P formation at the MAM, and apoptosis by blocking the DNM1L-dependent translocation of the proapoptotic protein BAX to mitochondria.
