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. 2017 Nov 25;13(11):1952–1968. doi: 10.1080/15548627.2017.1368596

Figure 3.

Figure 3.

Intermittent fasting does not improve glucose tolerance in Lamp2 heterozygous null mice with obesity-induced diabetes. (A) Body weight in WT female mice fed HFD (red, squares) or chow (blue, circles) for 12 wk, during the subsequent 6 wk of intermittent fasting (closed squares or circles with dotted lines) or ad-lib feeding (open squares or circles with solid lines) while being continued on the respective diets (n = 5/ group for chow feeding, n = 10/group for HFD, *P < 0.05 HFD-AL vs. chow-AL). (B) Body weight in Lamp2 heterozygous null mice fed HFD (green, squares) or chow diets (black, circles) for 12 wk during the subsequent 6 wk of IF (closed squares or circles with dotted lines) or ad-lib feeding (open squares or circles with solid lines) while being continued on the respective diets (n = 6/group for HF diet and n = 3 or 4/group for chow diet; *P < 0.05 HFD-AL vs. chow-AL). (C and D) Caloric intake in mice treated as in (A and B), respectively (*P < 0.05 for HFD-AL vs. chow-AL, #P < 0.05 HFD-IF vs. HFD-AL). (E and F) GTTs in WT females (E, n = 10/ group, *P<0.05 for HFD-AL vs. chow-AL, #P < 0.05 HFD-IF vs. HFD-AL, $P < 0.05 for chow-IF vs. chow-AL) and Lamp2 heterozygous null mice (F, n = 3 to 6 per group, *P < 0.05 for HFD-AL vs. chow-AL) fed HFD or chow diets followed by IF or ad-lib access to respective diets. (G and H) AUC measurements from GTTs performed in (E and F). (I and J) Insulin levels upon glucose challenge in obese WT (I, n = 5/group) and Lamp2 heterozygous null mice (J, n = 3 or 4/group) after IF or ad-lib feeding on HFD for 6 wk. *P < 0.05; **P < 0.001 and ***P < 0.0001.