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Schematic diagram of the mechanisms of CAR3 in maintaining homeostasis of CHRN. CAR3 interacts with BAG3 to inhibit chaperone-assisted selective autophagy (CASA), which regulates endocytosis of CHRN through interaction between BAG3-HSPA8 and CHRN. CAR3 also reduces ER stress, preventing excessive degradation of CHRN in muscle cells.
