Figure 8.

Effect of AdipoRon upon cardiac function and infarct size after MI-R. NC, DB, and adipoq^−/− mice were subjected to 30 min of MI followed by 24 h of reperfusion. Ten min before reperfusion, mice were randomized to receive vehicle or AdipoRon intravenous injection. (A) Representative records of echocardiography. (B) Left ventricular ejection fraction (LVEF) in NC, DB and adipoq^−/− mice subjected to sham MI-R, MI-R and MI-R treated with vehicle or AdipoRon. (C) Myocardial infarct size determined by Evans blue-TTC double-staining protocol demonstrating that AdipoRon significantly reduced infarct size in NC, DB, and adipoq^−/− mice. N = 12–15 mice/group. Data were analyzed by one-way ANOVA followed by the Tukey post hoc test for pairwise comparisons. *P < 0.05, **P < 0.01 between vehicle and AdipoRon-treated animals. Inf/AARx100%: Infarct size/Area-At-Risk x 100%.