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. 2018 Feb 25;208(2):491–511. doi: 10.1534/genetics.117.300386

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Copyright © 2018 by the Genetics Society of America

Available freely online through the author-supported open access option.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Functional antagonism between MES-4 and PRC2. The genome is organized into domains of genes expressed only in the germ line, or both in the germ line and broadly across cell types, and domains of genes with somatic cell and regulated expression. MES-4 marks genes transcribed in the germ line with H3K36me2/3. This includes germ line-specific genes (red) and broadly expressed genes (orange). A PRC2-like complex composed of MES-2, MES-3, and MES-6 marks somatic genes (gray) with H3K27me3. MES-4 inhibits PRC2: in mes-4(RNAi) embryos (derived from RNA interference-treated mothers), H3K27me3 marking spreads into regions previously occupied by H3K36me3.