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. 2017 Nov 29;208(2):673–686. doi: 10.1534/genetics.117.300468

Figure 6.

Figure 6

Knockout of lhx1 leads to a decrease in kidney developmental markers as seen by in situ hybridization. (A) Representative embryos showing that knockout of lhx1 leads to a decrease in hnf1β and atp1a1 expression in the pronephros, while slc45a2 knockout does not cause a decrease in these markers of kidney development. (B) lhx1 knockout in 1-cell embryos leads to a decrease in hnf1β and atp1a1 in comparison to slc45a2 knockout control embryos. (C) lhx1 knockout in 2-cell embryos leads to a decrease in hnf1β and atp1a1 in comparison to slc45a2 knockout control embryos. (D) lhx1 knockout in 8-cell embryos leads to a decrease in hnf1β and atp1a1 in comparison to slc45a2 knockout control embryos. I, injected side of embryo; U, uninjected side of embryo.