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Effect of mutated forms of VCP (A232E and R155H) on the formation of constitutive SGs and the recruitment of TARDBP to those SGs. HeLa cells were transfected with plasmid expressing wild-type or mutant VCP-GFP forms and stained for the SG marker EIF3B and TARDBP. Overexpression of mutant but not wild-type VCP resulted in the formation of TARDBP-containing SGs. Scale bar: 10 µm. Reproduced with permission from ref. 655.
