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. 2017 Dec 7;9(2):1705–1716. doi: 10.18632/oncotarget.23083

Figure 2. TRAIL inhibits initiation of CAC by blocking activation of β-catenin.

Figure 2

(A) C57BL/6 mice are treated with 2.5% DSS and 8 mg/kg AOM (N = 6 mice per group) and injected TRAIL (300 μg/kg) for 10 times within 10 days. The mice were sacrificed after 4 weeks to prepare the colon tissues. (B) After 4 weeks, colons were obtained and measured length and number of tumors. The arrows indicated the formed tumors. (C) Neoplastic colon tissues were stained with H&E. Scale bar denotes 100 μm. (D) To confirm the tumorigenesis of dysplastic residue, colon tissues of each group were immunostained with β-catenin. Scale bar denotes 50 μm. The positive cells were counted and compared with control groups. Results are presented as mean ± SD from three independent experiments.