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. 2017 Jun 29;9(2):1760–1771. doi: 10.18632/oncotarget.18880

Figure 3. Loss of epithelial marker E-cadherin correlates with worse overall survival.

Figure 3

Serial sections of FFPE NSCLC tissues (n = 41) were immunohistochemically stained for E-cadherin or vimentin. (A) Example images of week, moderate and intense E-Cadherin staining (left to right). (B) Matched image analysis (to A) produced by Image Scope Positive Pixel Algorithm with pixels coloured as weak (yellow), moderate (orange) or intense (red), extracted values were used to calculate a mean H-Score for each patient. (C) Patient survival based on E-Cadherin H-Score grouped as low or high (below or above) the mean H-Score. (D) Presence of vimentin staining in any of the tumour nests was categorised as positive, and total absence as negative. * = significance P <0.05 as measured by Log-rank (Mantel-Cox) between groups.