Table 1. Association of TME markers with overall survival in multivariate analysis.
| No. of Patients | No. of Deaths | HR (95%CI) | P Value | |
|---|---|---|---|---|
| Total | ||||
| CD8 | 62 | 30 | 1.091 (1.006-1.185) | 0.036 |
| CD68 | 62 | 30 | 1.007 (0.983-1.031) | 0.580 |
| FoxP3 | 62 | 30 | 0.955 (0.970-1.021) | 0.728 |
| Tumour Nest | ||||
| CD8 | 62 | 30 | 0.917 (0.842-0.998) | 0.044 |
| CD68 | 62 | 30 | 0.981 (0.940-1.025) | 0.396 |
| FoxP3 | 62 | 30 | 1.024 (0.977-1.074) | 0.319 |
| Stromal | ||||
| CD8 | 62 | 30 | 0.913 (0.842-0.991) | 0.029 |
| CD68 | 62 | 30 | 1.005 (0.982-1.029) | 0.654 |
| FoxP3 | 62 | 30 | 1.001 (0.977-1.026) | 0.951 |
| TN/STR | ||||
| CD8 | 62 | 30 | 0.645 (0.427-0.974) | 0.037 |
| CD68 | 62 | 30 | 0.889 (0.745-1.061) | 0.192 |
| FoxP3 | 62 | 30 | 0.920 (0.823-1.028) | 0.140 |
| CAF Markers | ||||
| Cav-1 | 62 | 30 | 0.635 (0.413-0.635) | 0.038 |
| Tn-C | 62 | 30 | 2.309 (1.287-4.143) | 0.005 |
| EMT Markers | ||||
| E-Cadherin | 41 | 22 | 1.642 (0.436-6.183) | 0.464 |
| Vimentin | 41 | 22 | 1.150 (0.180-7.329) | 0.883 |
| Combination | ||||
| CD8 TN/STR & High Cav-1 & Low Tn-C | 62 | 30 | 3.207 (1.907-5.392) | <0.001 |
Bold type indicates significance p<0.05. TN/STR= tumour nest: stromal ratio.