Table 2. Univariate and multivariate analysis for overall survival: Prognostic factors and histogram analysis parameters in the training dataset.
| Prognostic factor/parameter | N events/ N patients | Univariate analysis (n=313) | Multivariate analysis (n=301) | ||
|---|---|---|---|---|---|
| HR [95% CI] | p-Value (Wald) | HR [95% CI] | p-Value (Wald) | ||
| Smoker status | |||||
| Never | 33/50 | 1 | 0.001 | 1 | 0.002 |
| Former/current | 219/263 | 1.9 [1.3-2.7] | 1.8 [1.3-2.7] | ||
| Performance Status (UK=7) | |||||
| 0-1 | 194/247 | 1 | <.0001 | 1 | <0.0001 |
| >1 | 53/59 | 2.2 [1.6-3.0] | 2.3 [1.7-3.2] | ||
| Primary size tumor (UK=5) | 248/308 | 1.01 [1.00-1.01] | 0.005 | 1.0 [0.99-1.01] | 0.89 |
| Adrenal metastasis | |||||
| No | 186/241 | 1 | <.0001 | 1 | 0.002 |
| Yes | 66/72 | 1.9 [1.4-2.5] | 1.6 [1.2-2.2] | ||
| Liver metastasis | |||||
| No | 211/269 | 1 | 0.0004 | 1 | 0.003 |
| Yes | 41/44 | 1.8 [1.3-2.6] | 1.7 [1.2-2.4] | ||
| Coarse (2.2) (UK=5) | |||||
| Entropy | 251/312 | 1.3 [1.1-1.6] | 0.006 | - | - |
| Coarse (2.8) (UK=5) | |||||
| Entropy | 250/311 | 1.25 [1.1-1.5] | 0.007 | - | - |
| Coarse (3.3) (UK=5) | |||||
| Entropy | 248/308 | 1.3 [1.1-1.5] | 0.001 | 1.3 [1.1-1.5] | 0.002 |
UK: Unknown.