Table 3. Univariate and multivariate analysis for overall survival: prognostic factors and histogram analysis parameters in validation dataset.
| Prognostic factor/parameter | N evt/N pts | Univariate analysis (n=108) | Multivariate analysis (n=99) | ||
|---|---|---|---|---|---|
| HR [95% CI] | p-Value (Wald) | HR [95% CI] | p-Value (Wald) | ||
| Smoker status | |||||
| Never | 7/11 | 1 | 1 | ||
| Former/current | 76/95 | 1.8 [0.9-4.0] | 0.12 | 2.1 [0.8-5.1] | 0.11 |
| Performance Status | |||||
| 0-1 | 65/85 | 1 | 1 | ||
| >1 | 16/19 | 1.8 [1.0-3.1] | 0.039 | 1.6 [0.9-2.9] | 0.12 |
| Primary size tumor | 80/103 | 1.0 [0.99-1.01] | 0.70 | 1.0 [0.99-1.01] | 0.97 |
| Adrenal metastasis | |||||
| No | 49/91 | 1 | 0.21 | 1 | 0.01 |
| Yes | 11/17 | 1.5 [0.8-2.9] | 2.2 [1.2-4.0] | ||
| Liver metastasis | |||||
| No | 51/93 | 1 | 0.38 | 1 | 0.67 |
| Yes | 9/15 | 1.4 [0.7-2.8] | 1.2 [0.6-2.2] | ||
| Coarse (2.2) | |||||
| Entropy | 84/108 | 1.2 [0.7-2.1] | 0.59 | - | - |
| Coarse (2.8) | |||||
| Entropy | 84/108 | 1.2 [0.8-1.8] | 0.37 | - | - |
| Coarse (3.3) | |||||
| Entropy | 84/108 | 1.2 [0.9 - 1.6] | 0.18 | 1.1 [0.8-1.5] | 0.65 |