Figure 7. Repression of Tiam1 expression prevents cell growth in 3D lymphoma spheroids.

(A) Western blot and (B) immunofluorescence microscopy demonstrates the strong inhibition of Tiam1 expression by NSC23766 in 3D spheroids. (C) Phase contrast microscopy demonstrates a marked reduction in the size of EL4 cell spheroids by inhibition of endogenous Tiam1. Data represent the means ± SD of three independent experiments. ^*P < 0.05, ^**P < 0.01, and ^***P < 0.001 versus the control.