Table 3. Incidence density rates and hazard ratios of Parkinson's disease for the effect of tension-type headache stratified by sex, age, and comorbidity.
| Characteristics | Non-TTH group | TTH group | Compared to the non-TTH group | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | ||||||||
| Event no. | Person-years | IR | Event no. | Person-years | IR | Crude | Adjusted‡ | |
| Sex | ||||||||
| Women | 449 | 285389 | 1.57 | 204 | 72083 | 2.83 | 1.80 (1.52-2.12)*** | 1.41 (1.18-1.67)*** |
| Men | 259 | 134817 | 1.92 | 116 | 34099 | 3.40 | 1.77 (1.42-2.21)*** | 1.31 (1.04-1.66)* |
| Age, years | ||||||||
| 20-44 | 24 | 185474 | 0.13 | 30 | 47031 | 0.64 | 4.91 (2.87-8.40)*** | 2.71 (1.48-4.97)** |
| 45-64 | 201 | 169427 | 1.19 | 103 | 42482 | 2.42 | 2.04 (1.61-2.59)*** | 1.45 (1.13-1.87)** |
| ≥ 65 | 483 | 65304 | 7.40 | 187 | 16670 | 11.2 | 1.52 (1.28-1.79)*** | 1.24 (1.04-1.48)* |
| Comorbidity status† | ||||||||
| No | 144 | 263567 | 0.55 | 28 | 42659 | 0.66 | 1.19 (0.80-1.79) | 1.54 (1.03-2.31)* |
| Yes | 564 | 156639 | 3.60 | 292 | 63523 | 4.60 | 1.28 (1.11-1.47)*** | 1.56 (1.35-1.80)*** |
TTH, tension-type headache; IR, incidence density rates, per 1000 person-years; HR, hazard ratio; CI, confidence interval.
† Patients with any one of diabetes, hyperlipidemia, hypertension, IHD, dementia, depression, migraine, stroke, CKD, and head injury were classified as the comorbidity group.
‡ Model mutually adjusted for sex, age, diabetes, hyperlipidemia, hypertension, IHD, dementia, depression, migraine, stroke, CKD, and head injury.
* P<.05, ** P<.01, *** P<.001.