Table 1. IC50 of anticancer drugs in Reh cells and resistant cells.
Drugs | IC50 (μg/mL) | aRelative resistance | bRelative resistance | ||
---|---|---|---|---|---|
Reh | Reh-6MPR | Reh-6TGR | |||
6-MP | 0.18±0.02 | 174.23±16.75*** | 125.73±3.54*** | 968 | 699 |
6-TG | 0.09±0.01 | 104.50±2.79*** | 86.05±5.82*** | 1161 | 956 |
MTX | 0.005±0.0006 | 0.0039±0.0001 | 0.004±0.0002 | 0.78 | 0.80 |
AraC | 0.0024±0.0001 | 0.0018±0.0002 | 0.0016±0.0001 | 0.75 | 0.67 |
Values are given as mean ± SD. IC50 of resistant cells to 6-MP and 6-TG differed significantly from Reh cells, ***P<0.001 compared with Reh group. aRelative resistance was obtained by dividing the IC50 mean value of Reh cells by the IC50 value of Reh-6MPR cells; bRelative resistance was obtained by dividing the IC50 mean value of Reh cells by the IC50 value of Reh-6TGR cells.