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. 2017 Dec 19;9(2):2384–2394. doi: 10.18632/oncotarget.23415

Figure 3. ABC294640 inactivates SphK and STAT3 in C33A cells.

Figure 3

C33A cells were either left untreated (“C”) or treated with ABC294640 at designated concentrations (0.1-10 μmol/L), cells were further cultured for 24 hours; relative SphK activity (A), S1P content (B) and ceramide level (C) as well as STAT3 activation (D) were examined. p-STAT3 (vs. total STAT3) was quantified (D). Data were shown as mean (n=5) ± standard deviation (SD). *p<0.05 vs. “C” cells. Experiments in this figure were repeated three times, and similar results were obtained.