Table 3. Genotype distribution and lung cancer risk in smokers and non-smokers.
Genotype | Cases(%) | Controls(%) | OR(95% CI) | P value | ORadj.(95% CI) | Padj. | |
---|---|---|---|---|---|---|---|
Smokers | rs6495309 | ||||||
CC | 60(32.1) | 24(27.6) | Ref | 0.752 | Ref | 0.612 | |
CT | 88(47.1) | 44(50.6) | 0.800(0.441-1.452) | 0.463 | 0.770(0.421-1.408) | 0.396 | |
TT | 39(20.9) | 19(21.8) | 0.821(0.398-1.694) | 0.594 | 0.721(0.344-1.508) | 0.384 | |
CC+CT | 148(79.1) | 68(78.2) | Ref | Ref | |||
TT | 39(20.9) | 19(21.8) | 0.943(0.508-1.757) | 0.853 | 0.845(0.447-1.596) | 0.604 | |
rs8040868 | |||||||
TT | 70(37.4) | 41(47.1) | Ref | 0.316 | Ref | 0.262 | |
TC | 97(51.9) | 38(43.7) | 1.495(0.873-2.560) | 0.143 | 1.540(0.890-2.665) | 0.123 | |
CC | 20(10.7) | 8(9.2) | 1.464(0.592-3.623) | 0.409 | 1.595(0.641-3.973) | 0.316 | |
TT+TC | 167(89.3) | 79(90.8) | Ref | Ref | |||
CC | 20(10.7) | 8(9.2) | 1.183(0.499-2.802) | 0.703 | 1.265(0.532-3.007) | 0.595 | |
rs1948 | |||||||
CC | 42(22.7) | 24(27.6) | Ref | 0.408 | Ref | 0.284 | |
CT | 94(50.8) | 46(52.9) | 1.168(0.233-2.165) | 0.62 | 1.241(0.661-2.327) | 0.501 | |
TT | 49(26.5) | 17(19.5) | 1.647(0.781-3.647) | 0.19 | 1.834(0.859-3.912) | 0.117 | |
CC+CT | 136(73.5) | 70(80.5) | Ref | Ref | |||
TT | 49(26.5) | 17(19.5) | 1.484(0.796-2.765) | 0.214 | 1.584(0.845-2.968) | 0.151 | |
Non-smokers | rs6495309 | ||||||
CC | 25(23.4) | 54(24.7) | Ref | 0.726 | Ref | 0.642 | |
CT | 60(56.1) | 113(51.6) | 1.147(0.650-2.024) | 0.636 | 1.174(0.660-2.089) | 0.585 | |
TT | 22(20.6) | 52(23.7) | 0.914(0.459-1.818) | 0.797 | 0.894(0.445-1.796) | 0.752 | |
CC+CT | 85(79.4) | 167(76.3) | Ref | Ref | |||
TT | 22(20.6) | 52(23.7) | 0.831(0.473-1.459) | 0.52 | 0.800(0.451-1.418) | 0.445 | |
rs8040868 | |||||||
TT | 51(47.7) | 106(49.1) | Ref | 0.053 | Ref | 0.111 | |
TC | 43(40.2) | 100(46.3) | 0.894(0.548-1.458) | 0.653 | 0.900(0.574-1.478) | 0.676 | |
CC | 13(12.1) | 10(4.6) | 2.702(1.110-6.576) | 0.029* | 2.375(0.964-5.849) | 0.060 | |
TT+TC | 94(87.9) | 206(95.4) | Ref | Ref | |||
CC | 13(12.1) | 10(4.6) | 2.849(1.206-6.731) | 0.017* | 2.496(1.044-5.965) | 0.040* | |
rs1948 | |||||||
CC | 24(22.6) | 67(30.9) | Ref | 0.093 | Ref | 0.055 | |
CT | 65(61.3) | 105(48.4) | 1.728(0.988-3.024) | 0.055 | 1.896(1.069-3.362) | 0.029* | |
TT | 17(16.0) | 45(20.7) | 1.055(0.510-2.182) | 0.886 | 1.133(0.540-2.380) | 0.741 | |
CC+CT | 89(84.0) | 172(79.3) | Ref | Ref | |||
TT | 17(16.0) | 45(20.7) | 0.730(0.395-1.349) | 0.315 | 0.737(0.395-1.376) | 0.339 |
*P<0.05.