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. 2017 Dec 20;9(2):2435–2444. doi: 10.18632/oncotarget.23459

Table 3. Genotype distribution and lung cancer risk in smokers and non-smokers.

Genotype Cases(%) Controls(%) OR(95% CI) P value ORadj.(95% CI) Padj.
Smokers rs6495309
CC 60(32.1) 24(27.6) Ref 0.752 Ref 0.612
CT 88(47.1) 44(50.6) 0.800(0.441-1.452) 0.463 0.770(0.421-1.408) 0.396
TT 39(20.9) 19(21.8) 0.821(0.398-1.694) 0.594 0.721(0.344-1.508) 0.384
CC+CT 148(79.1) 68(78.2) Ref Ref
TT 39(20.9) 19(21.8) 0.943(0.508-1.757) 0.853 0.845(0.447-1.596) 0.604
rs8040868
TT 70(37.4) 41(47.1) Ref 0.316 Ref 0.262
TC 97(51.9) 38(43.7) 1.495(0.873-2.560) 0.143 1.540(0.890-2.665) 0.123
CC 20(10.7) 8(9.2) 1.464(0.592-3.623) 0.409 1.595(0.641-3.973) 0.316
TT+TC 167(89.3) 79(90.8) Ref Ref
CC 20(10.7) 8(9.2) 1.183(0.499-2.802) 0.703 1.265(0.532-3.007) 0.595
rs1948
CC 42(22.7) 24(27.6) Ref 0.408 Ref 0.284
CT 94(50.8) 46(52.9) 1.168(0.233-2.165) 0.62 1.241(0.661-2.327) 0.501
TT 49(26.5) 17(19.5) 1.647(0.781-3.647) 0.19 1.834(0.859-3.912) 0.117
CC+CT 136(73.5) 70(80.5) Ref Ref
TT 49(26.5) 17(19.5) 1.484(0.796-2.765) 0.214 1.584(0.845-2.968) 0.151
Non-smokers rs6495309
CC 25(23.4) 54(24.7) Ref 0.726 Ref 0.642
CT 60(56.1) 113(51.6) 1.147(0.650-2.024) 0.636 1.174(0.660-2.089) 0.585
TT 22(20.6) 52(23.7) 0.914(0.459-1.818) 0.797 0.894(0.445-1.796) 0.752
CC+CT 85(79.4) 167(76.3) Ref Ref
TT 22(20.6) 52(23.7) 0.831(0.473-1.459) 0.52 0.800(0.451-1.418) 0.445
rs8040868
TT 51(47.7) 106(49.1) Ref 0.053 Ref 0.111
TC 43(40.2) 100(46.3) 0.894(0.548-1.458) 0.653 0.900(0.574-1.478) 0.676
CC 13(12.1) 10(4.6) 2.702(1.110-6.576) 0.029* 2.375(0.964-5.849) 0.060
TT+TC 94(87.9) 206(95.4) Ref Ref
CC 13(12.1) 10(4.6) 2.849(1.206-6.731) 0.017* 2.496(1.044-5.965) 0.040*
rs1948
CC 24(22.6) 67(30.9) Ref 0.093 Ref 0.055
CT 65(61.3) 105(48.4) 1.728(0.988-3.024) 0.055 1.896(1.069-3.362) 0.029*
TT 17(16.0) 45(20.7) 1.055(0.510-2.182) 0.886 1.133(0.540-2.380) 0.741
CC+CT 89(84.0) 172(79.3) Ref Ref
TT 17(16.0) 45(20.7) 0.730(0.395-1.349) 0.315 0.737(0.395-1.376) 0.339

*P<0.05.