. 2017 Dec 20;9(2):2475–2501. doi: 10.18632/oncotarget.23504

Table 4. The upstream regulatory factors predicted by the differentially expressed genes.

Genes (fold change)	Upstream regulator (predicted activation state)
TXNIP (2.693), TUBG1 (-1.537), TSC22D3 (1.706), TPM1 (3.48), TNS3 (2.193), TIMP3 (-1.771), THBS1 (-2.63), THBD (1.513), TGFB2 (1.996), TFF1 (-8.121), STON1 (1.837), SMC2 (-1.556), SMAD3 (1.579), SLC39A6 (-1.791), SLC25A15 (-1.641), SLC22A5 (-1.523), SKP2 (-1.581), SIAH2 (-2.051), SERPINA3 (-2.487), S100A7 (-3.398), RND3 (1.866), RFC4 (-1.523), RERG (-2.806), RBL2 (1.922), RAMP3 (-2.416), RAD54L (-1.518), RAB31 (-1.86), PTTG1 (-1.559), PRSS23 (-6.334), POLE2 (-1.54), PLK2 (1.691), PKIB (-2.626), PIK3R3 (1.505), PGR (-4.753), PDZK1 (-1.893), OXTR (-1.755), ODC1 (-1.766), NUDT1 (-1.639), NRP1 (2.291), NR4A1 (-1.573), NPY1R (-4.334), NDRG1 (-2.091), MYO1B (2.154), MYBL1 (-2.614), MYB (-2.368), MXD4 (1.554), MCM7 (-1.513), MB (1.6), LHFPL2 (1.997), LDLR (-1.551), KITLG (-1.665), KCTD6 (-1.911), ITGAE (-1.527), INHBB (1.923), IL1R1 (3.252), IGFBP4 (-1.922), IGFBP3 (1.567), IGF2 (-1.678), HTRA1 (-1.536), HMGCS1 (-1.524), GREB1 (-13.924), GNS (1.533), GK (-1.578), GAL (-4.313), GAB2 (-2.236), FOXC1 (-2.738), FOS (-2.902), FADS1 (-1.745), EGR3 (-3.418), EFNA1 (1.542), DUSP10 (2.302), DNMT3B (-1.715), CYP24A1 (-1.564), CYP1A1 (2.667), CXCL12 (-3.468), CLSTN2 (-1.941), CDC25A (-1.535), CDC20 (-1.619), CCND1 (-1.83), CCNB2 (-1.527), CAV1 (-1.911), C8orf44-SGK3/SGK3 (-8.98), C3 (-1.635), BTG2 (2.085), BTG1 (1.671), BMP4 (1.505), BIK (1.867), BCL2 (-1.993), BCAS1 (3.124), ASCL1 (-7.006), ARL4A (1.862), AREG (-6.828), APOD (1.994), ANXA3 (1.906), ANXA1 (-2.307), ABCC5 (1.84)	β-estradiol (Inhibited)
XAF1 (4.874), USP18 (1.861), UGT1A6 (2.738), UBE2L6 (2.187), TRIM14 (1.668), TNFSF10 (5.984), TGM2 (1.923), STAT1 (2.36), SP110 (2.416), SP100 (3.8), SDC1 (1.621), SAMHD1 (1.632), SAMD9 (2.661), PPP2R2C (1.532), PLSCR1 (2.069), PARP9 (2.657), PARP12 (1.55), OAS3 (2.187), OAS2 (5.481), OAS1 (2.793), NT5E (3.149), MX1 (2.775), LGALS3BP (1.901), ISG15 (1.669), IFITM1 (1.524), IFIT5 (1.736), IFIT3 (4.302), IFIT2 (2.246), IFIT1 (3.769), IFI6 (1.817), IFI44L (4.28), IFI44 (2.135), IFI35 (1.839), IFI27 (1.519), HERC6 (1.569), EIF2AK2 (1.765), DDX60 (3.177), DDX58 (2.337), CMPK2 (3.124), CDKN2B (2.153), C19orf66 (1.839)	IFNA2 (Activated)

Genes (fold change)

Upstream regulator
(predicted activation state)

TXNIP (2.693), TUBG1 (-1.537), TSC22D3 (1.706), TPM1 (3.48), TNS3 (2.193), TIMP3 (-1.771), THBS1 (-2.63), THBD (1.513), TGFB2 (1.996), TFF1 (-8.121), STON1 (1.837), SMC2 (-1.556), SMAD3 (1.579), SLC39A6 (-1.791), SLC25A15 (-1.641), SLC22A5 (-1.523), SKP2 (-1.581), SIAH2 (-2.051), SERPINA3 (-2.487), S100A7 (-3.398), RND3 (1.866), RFC4 (-1.523), RERG (-2.806), RBL2 (1.922), RAMP3 (-2.416), RAD54L (-1.518), RAB31 (-1.86), PTTG1 (-1.559), PRSS23 (-6.334), POLE2 (-1.54), PLK2 (1.691), PKIB (-2.626), PIK3R3 (1.505), PGR (-4.753), PDZK1 (-1.893), OXTR (-1.755), ODC1 (-1.766), NUDT1 (-1.639), NRP1 (2.291), NR4A1 (-1.573), NPY1R (-4.334), NDRG1 (-2.091), MYO1B (2.154), MYBL1 (-2.614), MYB (-2.368), MXD4 (1.554), MCM7 (-1.513), MB (1.6), LHFPL2 (1.997), LDLR (-1.551), KITLG (-1.665), KCTD6 (-1.911), ITGAE (-1.527), INHBB (1.923), IL1R1 (3.252), IGFBP4 (-1.922), IGFBP3 (1.567), IGF2 (-1.678), HTRA1 (-1.536), HMGCS1 (-1.524), GREB1 (-13.924), GNS (1.533), GK (-1.578), GAL (-4.313), GAB2 (-2.236), FOXC1 (-2.738), FOS (-2.902), FADS1 (-1.745), EGR3 (-3.418), EFNA1 (1.542), DUSP10 (2.302), DNMT3B (-1.715), CYP24A1 (-1.564), CYP1A1 (2.667), CXCL12 (-3.468), CLSTN2 (-1.941), CDC25A (-1.535), CDC20 (-1.619), CCND1 (-1.83), CCNB2 (-1.527), CAV1 (-1.911), C8orf44-SGK3/SGK3 (-8.98), C3 (-1.635), BTG2 (2.085), BTG1 (1.671), BMP4 (1.505), BIK (1.867), BCL2 (-1.993), BCAS1 (3.124), ASCL1 (-7.006), ARL4A (1.862), AREG (-6.828), APOD (1.994), ANXA3 (1.906), ANXA1 (-2.307), ABCC5 (1.84)

β-estradiol
(Inhibited)

XAF1 (4.874), USP18 (1.861), UGT1A6 (2.738), UBE2L6 (2.187), TRIM14 (1.668), TNFSF10 (5.984), TGM2 (1.923), STAT1 (2.36), SP110 (2.416), SP100 (3.8), SDC1 (1.621), SAMHD1 (1.632), SAMD9 (2.661), PPP2R2C (1.532), PLSCR1 (2.069), PARP9 (2.657), PARP12 (1.55), OAS3 (2.187), OAS2 (5.481), OAS1 (2.793), NT5E (3.149), MX1 (2.775), LGALS3BP (1.901), ISG15 (1.669), IFITM1 (1.524), IFIT5 (1.736), IFIT3 (4.302), IFIT2 (2.246), IFIT1 (3.769), IFI6 (1.817), IFI44L (4.28), IFI44 (2.135), IFI35 (1.839), IFI27 (1.519), HERC6 (1.569), EIF2AK2 (1.765), DDX60 (3.177), DDX58 (2.337), CMPK2 (3.124), CDKN2B (2.153), C19orf66 (1.839)

IFNA2
(Activated)