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. 2017 Dec 15;9(2):2543–2552. doi: 10.18632/oncotarget.23274

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Copyright: © 2018 Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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DHA related mRNA-lncRNA regulation network (A) Nodes represent candidate DHA targets in K562 cells. Circular and triangle nodes represent mRNAs and lncRNAs, respectively. Red and blue colors represent up- and downregulation, respectively. Basic network features, including degree and topological coefficients (B) Pathways enriched for differential mRNAs (C) and GO terms enriched for differential mRNAs (green) and lncRNAs (yellow) (D) are ranked by -log10(P) and shown as bar plots. The steroid biosynthesis pathway shows four key dysregulated mRNAs (red rectangles) regulated by four dysregulated lncRNAs (E).