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. 2017 Dec 20;9(2):2591–2602. doi: 10.18632/oncotarget.23515

Figure 6. MELK inhibitor OTSSP167 inhibits Nb tumor growth.

Figure 6

(A and B) NGP-luciferase xenografts were treated with DMSO or 10 mg/kg of OTSSP167 daily for 14 days. After treatment cycles, tumors and corresponding kidneys were photographed (A) and weighted (B). (C) Mice with NB tumors were treated with DMSO or 10 mg/kg of OTSSP167 daily for 48 hours. Effects of OTSSP167 on Rb phosphorylation and apoptotic marker PARP cleavage in the established NB tumor in vivo were shown. (D) A working model of MELK function in NB cells was shown.