Table 3. Metabolites differentiating IDC from both benign and controls a) Tissue metabolites, b) Serum metabolites.

S. No	Metabolite	HMDB ID	FC (IDC/C)	AUC (IDC/C)	FC (IDC/B)	AUC (IDC/B)
a) Tissue
1	Histidine	HMDB00177	3.28	0.79	2.29	0.64
2	Glutamine	HMDB00641	4.60	0.87	2.38	0.73
3	Tyrosine	HMDB00158	8.73	0.96	3.19	0.83
4	Creatine	HMDB00064	4.32	0.85	2.36	0.72
5	Phenylalanine	HMDB00159	3.98	0.92	2.45	0.81
6	Lactic acid	HMDB00190	4.35	0.85	2.54	0.76
7	Adonitol	HMDB00508	2.22	0.78	1.64	0.70
8	3,7-Cholest-5-ene	HMDB00941	0.48	0.81	0.35	0.76
b) Serum
1	Ascorbic acid	HMDB00044	0.31	0.98	0.32	0.73
2	Tryptophan	HMDB00929	0.49	0.93	0.62	0.78
3	Tyrosine	HMDB00158	0.61	0.89	0.68	0.74
4	Phenylalanine	HMDB00159	0.57	0.91	0.66	0.76
5	Uric acid	HMDB00289	0.60	0.88	0.63	0.79
6	α-Ketoglutaric acid	HMDB00208	15.26	0.81	5.14	0.74
7	UDP	HMDB00295	0.43	0.91	0.46	0.83
8	Creatine	HMDB00064	0.53	0.83	0.63	0.76
9	Pyruvate	HMDB00243	0.31	0.85	0.40	0.78

HMDB ID: Metabolite ID obtained from HMDB database, FC: Fold change (FC>1.4), IDC/C: IDC against control, AUC: Area under the curve, IDC/B: IDC against benign.