Table 2. Univariate and multivariate logistic regression analysis for predicting Death Pace Analysis-defined FOLFIRI+B*6-benefiting patients.
| UNIVARIATE | ||||||
|---|---|---|---|---|---|---|
| Variable | Coefficient | Std. Error | Wald | Odds ratio | 95% CI | P |
| Hb (continuous) | -0.28939 | 0.12906 | 5.0274 | 0.7487 | 0.5814 to 0.9642 | 0.0249 |
| Neutrophils (continuous) | 0.16301 | 0.078995 | 4.2585 | 1.1771 | 1.0082 to 1.3742 | 0.0391 |
| Grading 1-2 vs 3 | 0.61291 | 0.36786 | 2.776 | 1.8458 | 0.8975 to 3.7959 | 0.0957 |
| # of metastatic sites, 1 vs ≥2 | 0.34927 | 0.21209 | 2.7118 | 1.418 | 0.9357 to 2.1489 | 0.0996 |
| WBCs (continuous) | 0.11209 | 0.073299 | 2.3384 | 1.1186 | 0.9689 to 1.2914 | 0.1262 |
| PLTs (continuous) | 0.0029769 | 0.001967 | 2.2905 | 1.003 | 0.9991 to 1.0069 | 0.1302 |
| Liver function tests, normal vs abnormal | 1.23474 | 0.89316 | 1.9112 | 3.4375 | 0.5970 to 19.7930 | 0.1668 |
| Sex, male vs female | 0.6346 | 0.46612 | 1.8535 | 1.8863 | 0.7565 to 4.7030 | 0.1734 |
| adjuvant chemotherpy, yes vs no | -0.71958 | 0.56889 | 1.5999 | 0.487 | 0.1597 to 1,4850 | 0.2059 |
| Resection of the primary, yes vs no | -0.46082 | 0.44581 | 1.0684 | 0.6308 | 0.2633 to 1.5113 | 0.3013 |
| primary tumor location, right vs left | 0.41468 | 0.50124 | 0.6845 | 1.5139 | 0.5668 to 4.0435 | 0.4081 |
| Time Dx to first-line (continuous) | -0.011158 | 0.016047 | 0.4835 | 0.9889 | 0.9583 to 1.0205 | 0.4868 |
| CEA (continuous) | 0.00012735 | 0.00024302 | 0.2746 | 1.0001 | 0.9997 to 1.0006 | 0.6003 |
| LDH, normal vs abnormal | 0.18529 | 0.39352 | 0.2217 | 1.2036 | 0.5565 to 2.6028 | 0.6378 |
| CA19.9 (continuous) | -0.000010998 | 0.000030538 | 0.1297 | 1 | 0.9999 to 1.0000 | 0.7188 |
| ALP, normal vs abnormal | 0.14764 | 0.79944 | 0.0341 | 1.1591 | 0.2419 to 5.5542 | 0.8535 |
| Age (continuous) | 0.0029536 | 0.020514 | 0.02073 | 1.003 | 0.9634 to 1.0441 | 0.8855 |
| ECOG PS, 0 vs 1 | -0.050858 | 0.53198 | 0.00914 | 0.9504 | 0.3350 to 2.6961 | 0.9238 |
| MULTIVARIATE | ||||||
| Variable | Coefficient | Std. Error | Wald | Odds ratio | 95% CI | P |
| Hb (continuous) | -0.25772 | 0.12979 | 3.9428 | 0.7728 | 0.5992 to 0.9967 | 0.0471 |
| Neutrophils (continuous) | 0.13862 | 0.080305 | 2.9797 | 1.1487 | 0.9814 to 1.3445 | 0.0843 |
Only variables found to be significant at univariate analysis (p < 0.05) were analysed in the multivariate analysis. Hb: haemoglobin; WBCs: white blood cells; PLTs: platelets, Dx: diagnosis; LDH: lactate dehydrogenase; ALP: alkaline phosphatase; ECOG PS: Eastern Cooperative Oncology Group Performance Status