Table 2. IL-36 cytokine expression in inflammatory diseases.
Diseases categories | IL-36 isoforms | Expression tissues | references |
---|---|---|---|
Psoriasis | IL-36α, β and γ | skin | [14, 42] |
PsA | IL-36a, IL-36Ra | synovium | [13] |
RA | IL-36α, β and γ | synovium | [43] |
SLE | IL-36α, IL-36γ | blood | [44] |
pSS | IL-36α,IL-36Ra, IL-36RA | labial salivary glands | [45] |
IBD | IL-36α, IL-36γ | colonic mucosa | [1, 46] |
ILD | IL-36α, IL-36γ | lung | [47, 48] |
Obesity | IL-36α | adipose tissue | [49] |