Skip to main content
. 2017 Dec 19;9(2):2931–2950. doi: 10.18632/oncotarget.23407

Figure 4. Schematic Diagram of Effects of Ginsenosides on ESR2-NCF1-ROS and ROS-JNK-Autophagy Pathway of Cancer Cells.

Figure 4

Ginsenoside activate estrogen receptor 2 (ESR2)-neutrophil cytosolic factor 1 (NCF1)-ROS signaling pathway. ROS then activate JNK which in turns phosphorylate Bcl-2 and release Beclin 1 and induce autophagy through up-regulation of ATG5, Atg7, LC3-I and LC3-II. →, Activation; ┤, Inhibition.