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. 2017 Dec 16;9(2):2951–2961. doi: 10.18632/oncotarget.23359

Table 1. Modified SELEX methods.

SELEX methods Principle Ref
In vivo Localizing target molecules inside a living cell [90]
Cell-based Targeting the whole live cell [91]
One-round step One selection rounds of aptamer generation [92]
In silico Computational docking technology [93]
Capillary electrophoresis Electrophoretic mobility based separation [94]
Magnetic bead-based Magnetic beads immobilization [95]
High-throughput sequencing-based High-throughput sequencing and bioinformatics analysis [96]
Ligand-guided selection Using specific antibody to compete with the target molecule [97]
Isogenic cell Isogenic cell line application in counter selection step [98]
Quantitative parallel aptamer selection system Combination of microfluidic, next generation sequencing, and in situ-synthesized arrays [99]