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A. Inhibition of JNK activity by SP600125 reduces protein levels of FOXO3a and BIM in cells with AraC-induced cell damage treated with D2/CA. The levels of cleaved Caspases 9 and 3 are also reduced in these cells. B. The reduction of the enhancement of the cell death by D2/CA by inhibition of JNK phosphorylation parallels the molecular changes shown in panel A. *= p < 0.05, when compared with AraC treated group. # = p < 0.05, when compared with corresponding control group. N=3
