Figure 4. Dynamic Changes in Expression of Genes in the Core Senescence Signature.
Each panel shows one of the 55 genes in the core signature at the indicated points before and after irradiation. All genes show a dynamic temporal behavior at the time points tested: day 0 (proliferation), day 4, day 10, and day 20 after irradiation. Notably, all genes show a similar trend in the three cell types tested: fibroblasts (yellow), keratinocytes (red), and melanocytes (magenta). Genes in red correspond to those that reached significance (p ≤ 0.01) at all time points tested. N = 6.
*p ≤ 0.05; **p ≤ 0.01.