Table 2. Distribution and interaction analysis of seven rare AMD-associated genetic variants across five geographical regions.
| Gene |
Difference in distribution between geographical regions# |
Interaction Analysis* |
Overall effect size‡ |
|---|---|---|---|
| p-value | p-value | OR (95%CI) | |
|
CFH rs121913059 (p.Arg1210Cys) |
0.004 |
0.665 |
24.2 (8.9–65.6) |
|
CFI rs141853578 (p.Gly119Arg) |
0.707 |
0.563 |
3.7 (2.5–5.7) |
|
C3 rs147859257 (p.Lys155Gln) |
0.665 |
0.680 |
2.8 (2.3–3.4) |
|
C9 rs34882957 (p.Pro167Ser) |
0.315 |
0.572 |
1.7 (1.5–2.0) |
|
CFH rs148553336 |
0.053 |
0.015 |
0.5 (0.4–0.6) |
|
CFH rs35292876 |
0.001 |
0.709 |
2.3 (2.0–2.6) |
| CFH rs191281603 | 0.735 | 0.980 | 0.9 (0.7–1.1) |
#Logistic Regression with Firth correction. Individual Wald Chi-Square from likelihood ratio test for each of the variants across the geographical regions. *Interaction Analysis: Effect sizes in entire study and interaction analysis to study potential differences in effect size between cohorts. ‡Overall effect size adjusted for geographical region. Bold values: p value considered significant after Bonferroni correction (p<0.007).