Table 5.
Pulmonary function tests and gas exchange variables before and after stem cell therapy
| Test | 7 days preinfusion | Infusion day | 1 day after infusion | 7 days after infusion | 30 days after infusion | p value |
|---|---|---|---|---|---|---|
| FVC (L) | 2.60 ± 1.05 | 2.58 ± 1.03 | 2.54 ± 0.98 | 2.56 ± 0.95 | 2.62 ± 1.01 | .64 |
| FEV1 (L) | 1.62 ± 0.51 | 1.61 ± 0.52 | 1.60 ± 0.30 | 1.64 ± 0.47 | 1.66 ± 0.47 | .73 |
| FVC/FEV1 | 0.63 ± 0.11 | 0.64 ± 0.10 | 0.64 ± 0.10 | 0.69 ± 0.11 | 0.66 ± 0.12 | .11 |
| FEF25–75 (L/s) | 0.98 ± 0.45 | 0.84 ± 0.39 | 0.89 ± 0.39 | 0.94 ± 0.42 | 0.97 ± 0.45 | .11 |
| FiO2 | 0.22 ± 0.03 | — | — | 0.22 ± 0.03 | 0.22 ± 0.03 | — |
| pH | 7.41 ± 0.03 | — | — | 7.41 ± 0.02 | 7.42 ± 0.02 | .80 |
| PaCO2, mmHg | 39.10 ± 3.90 | — | — | 39 ± 4.90 | 38.30 ± 3.20 | .34 |
| PaO2, mmHg | 80.20 ± 8.60 | — | — | 81.30 ± 10.70 | 79.10 ± 10.50 | .92 |
| SaO2, % | 94.90 ± 1.30 | — | — | 94.90 ± 2.00 | 94.50 ± 1.70 | .75 |
| PaO2/FiO2 | 372 ± 67 | — | — | 373 ± 58 | 365 ± 73 | .99 |
Abbreviations: —, no data; FEF25–75, forced expiratory flow at 25%–75%; FEV1, forced expiratory volume in 1 second; FiO2, fraction of inspired oxygen; FVC, forced vital capacity; FVC/FEV1, forced vital capacity to forced expiratory volume in 1 second ratio; PaCO2, partial pressure of carbon dioxide in arterial blood; PaO2, partial pressure of oxygen in arterial blood; PaO2/FiO2, partial pressure of oxygen in arterial blood to fraction of inspired oxygen ratio; SaO2, percent saturation of oxygen in arterial blood.