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. 2017 Dec 27;7(2):197–209. doi: 10.1002/sctm.17-0086

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© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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CytoD affects genes linked to nuclear architecture. Quantitative PCR analysis on MSCs treated with CytoD over a 6‐day period showed downregulation of nuclear envelope genes SUN1 and SUN2, as well as lamin genes LMNA and LMNB1, associated with a decrease in mRNA levels of nuclear chromatin‐related EZH2; *, p < .05. Abbreviations: CytoD, cytochalasin D; EZH2, Enhancer of Zeste Homolog 2; LMNA, Lamin A; LMNB1, Lamin B1; REU, relative expression units.