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. 2018 Jan 25;8:7. doi: 10.3389/fcimb.2018.00007

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Copyright © 2018 Du, Yu, Pang, Xu, Mao, Yuan, He and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mucosal immune response in mice induced by different PRRSV vaccine formulations. Female BALB/c mice (6–8 weeks old, n = 7 in each group) were orally immunized with 100 μL PBS, pcDNA3.1-SynORF5, GP5, PLGA-SynORF5, PLGA-GP5, UEA-1/PLGA-SynORF5, or UEA-1/PLGA-GP5 at 0 and 2 weeks. Intestinal samples were collected at 42 dpi to determine the GP5-specific IgA antibody by ELISA. Data represent the mean ± s.e.m. for 7 mice per group. Columns with different letters differ significantly (P < 0.05).