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. 2018 Jan 25;9:60. doi: 10.3389/fimmu.2018.00060

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Copyright © 2018 Doorduijn, Sluijter, Querido, Seidel, Oliveira, van der Burg and van Hall.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Splenocytes and dendritic cells from TAP1^−/− mice present non-mutated neoantigens. T cell clones were tested against titrated numbers of splenocytes (A) and dendritic cells (B) from wild-type B6 or TAP1^−/− mice. The TLR4 ligand LPS was added to target cells to activate them. A twofold titration of target cells was tested, starting with 20,000 cells (splenocytes) or 10,000 cells (DC) per well. IFNγ release by T cells was determined as a measure of reactivity. Data are shown as mean with SD of triplicates from one out of two similar experiments. n.d., not determined.