Table 1.

T cell receptor specificity.

aa position
1	2	3	4	5	6	7	8	9
I	L	I	Y	H	F	R	G	Va
R	L	I	I	H	F	R	D	Ib
A	L	I	F	H	C	I	A	F
C		V	I	I	F	K	C	I
D			L	Y	M	M	D	L
E			V		Q	P	E	M
F			Y		V	R	F	V
G						V	G
H							H
I							I
K							L
L							M
M							N
N							P
P							Q
Q							R
R							S
S							T
T							V
V							W
W							Y
Y

^aAll positions of the agonistic peptide ILIYHFRGV were replaced and tested with Ln12 T cells (Table S1 in Supplementary Material), resulting in the indicated susceptible aa.

^bAll natural peptides fulfilling this motif were tested with Ln12 (Table S2 in Supplementary Material), yielding the Med15 peptide (RLIIHFRDI).