Table 1.

Shared upregulated genes in murine and human tissue/microglia across central nervous system afflictions.

	Murine models of chronic neurodegeneration							Human AD	Murine glioblastoma	Human glioblastoma
	Total cortex			Acutely isolated microglia				Cortex	Acutely isolated microglia	Tumor tissue
	ME7 Prion	APP/PS1 AD	5xFamilial AD	APP/PS1 AD end-stage	APP/PS1 AD CD11c+	CVN AD CD11c+	SOD1 g93a ALS Spinal cord	GL261 glioblastoma
CD11c/Itgax	+++	++	++	+	+	+++	++	ND	+	+
Dectin-1/Clec7a	+++	++	++	+	+		++	+	+	+
DC-HIL/Gpnmb	++	++	+	+++	++	+++	+++	+	++	+
PD-1/Pdcd1	++	++	+	+	+	+++	+	ND		+
OPN/Spp1	++	+		+	++	+++	+++	+	++	+
ILT3/Lilrb4	++	+	+	+	+	+++	++	+	+	+

A comparison of transcriptomic studies reveals shared upregulated genes in microglia across multiple neurodegenerative diseases. ME7 Prion (57) (compared to normal brain homogenate), APPswePS1dE9 (APP/PS1) (58) (compared to age-matched control), 5XFAD (59) (compared to age-matched control), APP/PS1 end-stage microglia (60) (compared to age-matched WT controls), APP/PS1 CD11c⁺ microglia (61) (compared to CD11c⁻ microglia), CVN AD CD11c⁺ microglia (62) (compared to CVN AD CD11c⁻ microglia), SOD1 g93a ALS spinal cord microglia (63) (compared to age-matched WT controls), Human AD (64) (compared to age-matched non-demented controls), GL261 glioblastoma microglia (65) (compared to age-matched WT microglia), Human glioblastoma tissue (TCGA database; compared to non-diseased tissue); ND, not determined; Blank, unknown. += > 2-fold, ++ = > 10-fold, +++ = > 50-fold.