Fig. 5.

Sources of phenotypic robustness mobilized by the VRN with respect to internal and external perturbation. a Sources of phenotype robustness in a metabolic network. b Classification and distribution of genes contributing to robustness of the proliferation phenotype (n = 78 for VRN-regulated genes and 839 for VRN-independent genes) and the T3SS-dependent secretion of the effector RipG7 (n = 78 for VRN-regulated genes and 521 for VRN-independent genes) obtained with the BECO analysis. Dependency of the two distributions, VRN-regulated vs VRN-independent, is shown and significance of the differences was assessed by performing a χ²-test. In total 919 metabolic genes were classified by the BECO analysis